Efficient identification of somatic mutations in acute myeloid leukaemia using whole exome sequencing of fingernail derived DNA as germline control
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چکیده
منابع مشابه
Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype.
Among acute myeloid leukemia (AML) patients with a normal karyotype (CN-AML), NPM1 and CEBPA mutations define World Health Organization 2008 provisional entities accounting for approximately 60% of patients, but the remaining 40% are molecularly poorly characterized. Using whole-exome sequencing of one CN-AML patient lacking mutations in NPM1, CEBPA, FLT3-ITD, IDH1, and MLL-PTD, we newly identi...
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*Vera Grossmann,1 *Enrico Tiacci,2 Antony B. Holmes,3 Alexander Kohlmann,1 Maria Paola Martelli,2 Wolfgang Kern,1 Ariele Spanhol-Rosseto,2 Hans-Ulrich Klein,4 Martin Dugas,4 Sonja Schindela,1 Vladimir Trifonov,3 Susanne Schnittger,1 Claudia Haferlach,1 Renato Bassan,5 Victoria A. Wells,6 Orietta Spinelli,5 Joseph Chan,3 Roberta Rossi,2 Stefano Baldoni,2 Luca De Carolis,2 Katharina Goetze,7 Hube...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-31503-5